• Concurrent BMP signalling maintenance and TGF-β signalling inhibition is a hallmark of natural resistance to muscle atrophy in the hibernating bear 

      Cussonneau, Laura; Boyer, Christian; Brun, Charlotte; Deval, Christiane; Loizon, Emmanuelle; Meugnier, Emmanuelle; Gueret, Elise; Dubois, Emeric; Taillandier, Daniel; Polge, Cecile; Bechet, Daniel; Gauquelin-Koch, Guillemette; Evans, Alina; Arnemo, Jon Martin; Swenson, Jon; Blanc, Stéphane; Simon, Chantal; Lefai, Etienne; Bertile, Fabrice; Combaret, Lydie (Peer reviewed; Journal article, 2021)
      Abstract: Muscle atrophy arises from a multiplicity of physio-pathological situations and has very detrimental consequences for the whole body. Although knowledge of muscle atrophy mechanisms keeps growing, there is still ...
    • Specific shifts in the endocannabinoid system in hibernating brown bears 

      Boyer, Christian; Cussonneau, Laura; Brun, Charlotte; Deval, Christiane; Pais de Barros, Jean-Paul; Chanon, Stéphanie; Bernoud-Hubac, Nathalie; Daira, Patricia; Evans, Alina L.; Arnemo, Jon Martin; Swenson, Jon; Gauquelin-Koch, Guillemette; Simon, Chantal; Blanc, Stéphane; Combaret, Lydie; Bertile, Fabrice; Lefai, Etienne (Peer reviewed; Journal article, 2020)
      In small hibernators, global downregulation of the endocannabinoid system (ECS), which is involved in modulating neuronal signaling, feeding behavior, energy metabolism, and circannual rhythms, has been reported to possibly ...